Disengagement is one of the many mutations you can acquire in Dead Cells. It’s also one of the many mutations you won’t be able to unlock without its blueprint. You’ll need to find that first to bring to the Collector.
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Where to Find the Disengagement Mutation Blueprint
You can find the blueprint for the Disengagement mutation in a secret area in the Prisoner’s Quarters.
To reach the secret area, though, you’ll first need to defeat the Hand of the King for the first time. This means you’ll need to beat the game once before you can proceed to obtain the blueprint.
Once that’s done, you then obtain the Homunculus Rune. This allows you to detach your head from your body and control it to reach previously inaccessible areas.
With that, at the beginning of your run, stand to the right of the axe and press R3 or RS to control your head. Walk to the left and jump onto the ledges.
Once you reach the top, jump to the opposite platform to land on a secret spot. From here, navigate to the blueprint, which you’ll already see from where you are.
As soon as you reach it, press R3 or RS once more and the head will travel back to your body, along with your newly acquired blueprint.
How to Unlock the Disengagement Mutation
Give the blueprint to the Collector. You’ll need to exchange 200 cells to unlock the mutation.
Once that’s done, you can interact with Guillain to equip the Disengagement colorless mutation.
This mutation will protect you with a forcefield once your HP falls under 15%. This forcefield will persist for 5 seconds. It has a 120-second cooldown.